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Malassezia pachydermatis, a yeast that has not previously been implicated as a cause of human disease, was isolated from cultures of blood from three infants. Dexamethasone (DEX) is a potent immunosuppressive agent used in the treatment of several disorders. Currently, few options exist to treat central nervous system (CNS) aspergillosis, which is usually fatal. Aspergillomas are fungal balls within lung cavities. The Tel Dan inscription, or "House of David" inscription, was discovered in 1993 at the site of Tel Dan in northern Israel in an excavation directed by . With the urgent need for novel agents to combat emerging fungal resistance to existing drugs, activity in the exploration of small molecule DNA binders has increased. In 2003 I co-led aprojectto put current meter moorings in Shag Rocks Passage and undertake a hydrographic survey of the North Scotia Ridge. To enable future studies on host resistance factors and therapy, inbred and outbred mouse strains were tested for susceptibility to vaginal candidiasis. A blurring of the roles of the three categories of dogs occurred when these programs were put into place at SCVMC. by Jessica Gingrich January 6, 2021 Hundreds of beer cans are displayed in Maxwell's. Murine BAM killed Aspergillus fumigatus conidia by 33 +/- 4% (mean +/- SD) in a 2.5-h assay, unaffected by GM-CSF treatment. AMB was given intraperitoneally (i.p. We found that polymorphonuclear neutrophils (PMN) from young mice had deficient fungicidal activity against Bd (37%) compared with adult PMN (80%). A high intermittent dose regimen (group A: 10 mg kg(-1) on day 1, 5 mg kg(-1) on days 3 and 6) was compared with standard dosing (group B: 3 mg kg(-1) per day for 14 days) of liposomal amphotericin B (LAB) for empirical treatment of persistent febrile neutropenia. The pharmacokinetics of a conventional and an intermittently administered high-dose regimen liposomal amphotericin B are linear. Developmental studies showed that suppression of mice with 5-fluorouracil beginning 3 days prior to infection and given every 7 days thereafter necessitated antibacterial treatment but resulted in a reproducible model. Killing by BAM treated with DEX (10(-7) M) for 48 h in vitro was reduced to 13 +/- 6%; however, if GM-CSF (500 U ml(-1)) was present during DEX treatment of BAM, killing of conidia (33 +/- 2%) by BAM was preserved. The third metabolite was a 1-dehydro-hydroxyprogesterone, but the location of the hydroxyl group could not be determined unequivocally. Cells were unstimulated or stimulated with conidia and simultaneously treated with DEX, GM-CSF, or DEX plus GM-CSF, for 2-4 hours. Micafungin at 0.01 or 0.10 microg/ml and PMNs resulted in additive inhibition, 82% and 99%, respectively. The decision to taper corticosteroids should be made on an individual basis, depending on the clinical course (BIII). My research can be broken down into three main areas: I am also interested in (though publish less frequently on) ethical and moral questions, such as killing and harming, just war theory, nationality and the structure of moral obligations. Many of the molecular mechanisms of resistance have been defined with matched sets of susceptible and resistant clinical isolates from the same strain. View details for DOI 10.1128/AAC.48.9.3407-3411.2004, View details for Web of Science ID 000223625800029. All drug regimens prolonged survival (P < or = 0.0008) and reduced cfu (P < or = 0.0001-0.003) recovered from the brains and kidneys compared with untreated. Thus, the choice of which animal model to use must be made carefully, addressing issues of the type of human disease to mimic, the parameters to follow and collection of the appropriate data to answer those questions being asked. In all studies, 90% of mice infected with 10(7) CFU of YJM128 died between days 2 and 7, whereas no mice infected with equivalent numbers of Y55 died. Caspofungin was not as effective against the larger inoculum, but did not enhance or interfere with the efficacy of Abelcet. BALB/c, the reference strain in repeated experiments, was susceptible, showing persistent infection with levels of cfu at day 6 falling within a range between a twofold decrease and a fourfold increase in relation to day 1 levels. No treatment regimen differed in efficacy. View details for Web of Science ID A1994NB82100004, View details for PubMedCentralID PMC1205906. Kim, K. K., Lee, K. C., Jeong, H., Stevens, D. A., Lee, J. Among the Candida species causing bloodstream infections, Candida parapsilosis is one of the most frequently isolated. Coccidioidal infections are often difficult to treat, and outcomes can be poor. Central nervous system (CNS) aspergillosis is a severe disease that responds poorly to current therapies. D-optimal design provided maximally informative sampling times for future pharmacokinetic studies. Beta-1,6-glucan declined 73%. of Chemistry, and Div. View details for Web of Science ID 000171998800004. Whereas panmixia expected of a single freely recombining population was not observed, recombination was detected when PS1 and PS2 were assessed separately, suggesting reproductive isolation. McCullough, M. J., Clemons, K. V., FARINA, C., McCusker, J. H., Stevens, D. A. We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. Drug efficacy in treating localized infection and in preventing or treating disseminated infection can be studied. Born in . The importance of C5 was confirmed by studies using B10.D2/oSnJ (C5-) mice and their congenic C5+ counterparts. As part of such collaborations, Dorian Fuller, Zhang Hai (PKU), and Chris have been working on the domestication and spread of millets in China. Invited essay in The SAA Archaeological Record 11(4). > present (Patron of the Association of Science and Discovery Centres), [????] and more from FamousFix.com. | Art UK", https://en.wikipedia.org/w/index.php?title=Joseph_Stevens_(archaeologist)&oldid=1084872919, This page was last edited on 27 April 2022, at 03:03. Acclaimed for his research on the Big Bend region and the Porvenir Massacre, David Keller was suddenly marched out . View details for DOI 10.1016/j.vaccine.2009.03.030 Isolation and identification of the progesterone metabolites confirm the production of 15 alpha-hydroxyprogesterone. Coccidioidal meningitis is a lethal disease, and current therapy is not curative or is burdened with serious toxicities and logistic difficulties. Also known as: Kimberly David Stevens, David Kstevens Or, Kimberly Stevens. Dexamethasone (DEX) down-regulates production of these cytokines by stimulated bronchoalveolar macrophages (BAM) and constitutes a risk factor for aspergillosis. Our results show susceptibility to vaginal candidiasis is independent of the major histocompatibility locus H2 haplotype and any effect ascribable to use of particular commercial mouse suppliers. View details for Web of Science ID 000166958800032. In an assessment of innate responses, we found spleen cells from young mice produced three-fold less IFN-gamma and three-fold less IL-2 than adult spleen cells in response to 1 microg/ml concanavalin A (Con A). View details for DOI 10.1016/j.ccr.2010.02.027. In addition, YJM128 increased by 4-fold in the kidneys, whereas Y55 decreased by 16-fold. A pathogenic role for M. pachydermatis recovered from sources other than blood or catheters was not established. I teach within the fields of ethics and contemporary political theory/philosophy. Recovered colonies were counted and confirmed as grand or petite, and the frequency of petite colonies in the brain, the target organ, correlated with the in vitro results. For example, a "no pet allowed" policy could not apply to these animals. S. cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the study of polygenic traits. It has been shown by us and others that progesterone inhibits the growth of Trichophyton mentagrophytes and that the organism escapes from this inhibition over time. It describes a range of group problem solving methodologies and illustrates vividly how they can aid modern business. Lou, L., Velligan, M., Roberts, C., Stevens, D. A., Clemons, K. V. Zeamatin, clotrimazole and nikkomycin Z in therapy of a Candida vaginitis model. In addition, clearance of the infection from both tissues was achieved in none of the rabbits, and neither tissue was cleared of infection in AMB-treated animals. > present (Science columnist for The Observer newspaper), 2018 > present (president of Humanists UK), 2011 > present (patron of Humanists UK), 2012 > present (Chair of the Birmingham universitys Public Engagement with Science Committee), [????] A systemic model of candidiasis was studied in CD-1 mice by intravenous inoculation of different isolates of C. albicans. of Pulmonary & Critical Care Med. View details for Web of Science ID 000239840700039. videos, Often, making television documentaries can be very un-family-friendly work. The antifungal activity of voriconazole (VCZ) was tested against Cryptococcus neoformans (Cn) with and without the addition of polymorphonuclear neutrophils (PMN), monocytes or monocyte-derived macrophages (MDM) in vitro. Nicola Harrington told National Geographic, "the cones (were) worn in the presence of the divine," she said. BAKER, G., FALK-WHYNES, J. and SIDOROVITCH, A., eds., Teaching for Integrative Learning: Innovations in University Practice. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Hepatotoxicity may contribute to high-dose Abelcet and AmBisome failures. Experimental Central Nervous System Aspergillosis Therapy: Efficacy, Drug Levels and Localization, Immunohistopathology, and Toxicity. Walsh, T. J., Raad, I., Patterson, T. F., Chandrasekar, P., Donowitz, G. R., Graybill, R., Greene, R. E., Hachem, R., Hadley, S., Herbrecht, R., Langston, A., Louie, A., Ribaud, P., Segal, B. H., Stevens, D. A., van Burik, J. H., White, C. S., Corcoran, G., Gogate, J., Krishna, G., Pedicone, L., Hardalo, C., Perfect, J. R. Experimental animal models of coccidioidomycosis. View details for DOI 10.1128/AAC.01538-08, View details for Web of Science ID 000265528700019, View details for PubMedCentralID PMC2681538. Immunosuppressed mice were infected intracerebrally with Aspergillus fumigatus and treated with an amphotericin B preparation, an echinocandin, or voriconazole (VCZ) given alone or in combination. Does the lack of increase in CFU as infection worsens inadequately reflect fungal load in the tissue? Conclusions: A proper IL-12 treatment protocol induces resistance (survival and decreased growth in lungs), low toxicity, macrophage responsiveness to IFN-gamma for killing Blastomyces, up-regulation of IFN-gamma and down-regulation of IL-10 production. All infected rabbits had neurological abnormalities and severe vasculitis in the basilar arteries on days 9-20. Antiquity 87 (335), 64-78, 2013. At six weeks, just 55% of women are breastfeeding. We have recently noted tracheobronchitis in six patients with heart-lung and lung transplants, three of whom had deep mucosal ulceration and histologic evidence of invasive aspergillosis. From my own experience, breastfeeding (and I know I was lucky my babies took to breastfeeding immediately, and I loved it; I had some difficulties, but nothing that Lansinoh and nipple shields couldnt help me overcome), breastfeeding was a joyful, lovely experience part of caring for a baby that I wouldnt want to have missed out on, and really important for bonding. Hypokalaemia tended to be less severe in group A with a lower proportion of hypokalaemic days [57/143 (39 %) vs 80/137 (58 %), P=0.21], a higher AUC(POTASSIUM) (A : B ratio of 1.06, P=0.12), a lower proportion of patients with hypokalaemia at the end of study (10 vs 61 %, P=0.01) and fewer potassium-supplemented days [12/210 (6 %) vs 41/210 (19.5 %), P<0.1]. View details for DOI 10.1007/978-1-61779-539-8_41. These findings expand our knowledge of the different morphological forms of P. brasiliensis during growth in culture. Cells treated with amphotericin B (AmB), micafungin (MF), and voriconazole (VCZ), at concentrations not affecting cell viability, reduced production of tumor necrosis factor (TNF)-alpha in response to conidia, with the greatest reduction noted with VCZ. Marked CFU reduction by AmBisome at 3 mg/kg occurred in association with relatively more intense inflammation. Utah Department of Transportation. Here, we examined the population genetic structure and geographic differentiation of the sexual, dimorphic fungus Blastomyces dermatitidis, the causative agent of blastomycosis.Criteria for Genealogical Concordance Phylogenetic Species Recognition (GCPSR) applied to seven nuclear loci (arf6, chs2, drk1, fads, pyrF, tub1, and its-2) from 78 clinical and environmental isolates identified two previously unrecognized phylogenetic species. We studied potential therapeutic options in a murine model of pulmonary aspergillosis in triamcinolone-suppressed DBA/2 mice infected intranasally with conidia from Aspergillus fumigatus. Animal models of aspergillosis have been used extensively to study various aspects of pathogenesis, innate and acquired host-response, disease transmission and therapy. Weger, S. D., Ganji, A., Clemons, K. V., Byron, J. K., Minn, Y., Stevens, D. A. Homozygosity at the Candida albicans MTL locus associated with azole resistance. Our data suggest that SP-D in BALF binds beta-glucan on B. dermatitidis, blocking BAM access to beta-glucan, thereby inhibiting TNF-alpha production. The resistance seen in mouse strain CD-1 is of particular interest in that CD-1 is known to be resistant to endocrine disruption by estrogen. Seven of the eight isolates from HCW were RFLP subtype VII-1. This study indicates that treatment of mallard ducks with VRC might require a dosing interval of at least every 8-12 h at a dose of 20 mg/kg, but further studies are necessary. A 16.5% salt concentration in brain-heart infusion broth, incubated at 35 degrees C for 48-72 hours, then subcultured to agar plates incubated in room air at 35 degrees C, proved optimal for selection and secondary isolation. 1,398 Followers, 664 Following, 206 Posts - See Instagram photos and videos from DAVID STEVENS | Photographer (@davidstevens.photo) Liu, M., Capilla, J., Johansen, M. E., Alvarado, D., Martinez, M., Chen, V., Clemons, K. V., Stevens, D. A. Clemons, K. V., Martinez, M., Calderon, L., Stevens, D. A. View details for DOI 10.1371/journal.pone.0059237, View details for Web of Science ID 000316549400044. These results indicate that AmBi in combination with VCZ may be superior for treatment of CNS aspergillosis; combinations of AmBi and MICA or CAS were not antagonistic and may have a slight benefit. David Stevens, Baron Stevens of Ludgate (born 1936), Conservative Independent peer in the House of Lords David Stevens (businessman) (born 1962), British businessman, CEO of Admiral Group David Stephens, vocalist for the band We Came as Romans Dave Stevens (1955-2008), illustrator Dave Stevens (baseball) (born 1970), American baseball player View details for DOI 10.1128/AAC.00332-06, View details for Web of Science ID 000244665500028, View details for PubMedCentralID PMC1803148. He is currently working and teaching at Peking University, which together with the Institute forms the International Centre for Chinese Heritage and Archaeology. View details for Web of Science ID 000220735200015. 0 Reviews. Overall, these studies show an inverse correlation between the frequency of petite-colony formation and the previously determined virulence of S. cerevisiae in CD-1 mice. WWW2006 15th International World Wide Web Conference. These facts, together with recent advances in vaccine science, make consideration of such an approach now possible. van Asbeck, E., Clemons, K. V., Martinez, M., Tong, A., Stevens, D. A. Stevens, D. A., White, T. C., Perlin, D. S., Selitrennikoff, C. P. Advances against aspergillosis (September 9-11, 2004, San Francisco, California). The two earlier meetings had taken place in San Francisco, CA, 2004 and in Athens, Greece, 2006, and the series has become the place for scientists and clinicians to be updated on developments relevant to all aspects of this fungal genus. In 24 medical centers, we examined the impact of a culture positive for Aspergillus species on the diagnosis, risk factors, management, and outcome associated with these diseases. Coccidioidal meningitis is lethal in the absence of treatment. The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus, Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus, Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (nikkomycin Z) for inhibition and killing of fungal pathogens, Practice guidelines for diseases caused by Aspergillus. ; Univ. Help us build our profile of Alice Roberts! View David Stevens's Family Tree and History, Ancestry and Genealogy, Professor of Public Engagement in Science, The Red Maids' School, Bristol, England, United Kingdom, University of Wales, Cardiff, Glamorgan, Wales, United Kingdom However, the literature is growing that this mycosis, particularly pulmonary aspergillosis, can be seen in patients lacking these factors. Its clear that some women feel bullied by health professionals, and that cant be helpful. [2] Contents 1 Personal life Like a superhero of the coiffe, she spends her days as a regular hair dresser, giving people layers and funky bobs. The growth of A. benhamiae + and -, M. canis, and T. rubrum were all inhibited by progesterone in a dose-responsive manner, with 50% inhibition achieved at concentrations of 9.8 x 10(-6), 1.2 x 10(-5), 1.5 x 10(-5), and 2.7 x 10(-6) M. respectively,. IL-2 production by BALB/c spleen cells in response to Con A was 3- to 4-fold greater than that by CD-1 spleen cells. Once detected, each remained at a relatively constant level through 28 days of infection. Therefore, C. albicans and C. dubliniensis genotype distribution differences in Israel are related to changes in all ethnic groups. The fungal genes responsive to estrogen action are under study. To catch up with our other motherhood content, click here. The collection was assembled so that approximately half of the isolates were resistant to azole drugs. There was no apparent relation between dose, time after dose, site of CSF sampling, or concurrent inflammation and CSF ketoconazole concentration. (ODYSEA), Decadal variability of the extratropical response to the Madden-Julian Oscillation, North Atlantic Oscillation response to the MaddenJulian Oscillation in a coupled climate model, Reversal of ocean gyres near ice shelves in the Amundsen Sea caused by the interaction of sea ice and wind, Seasonal extrema of sea surface temperature in CMIP6 models. In the initial study, groups of mice were given saline, or 1, 3 or 10 mg kg(-1) of MICA b.i.d., s.c. All saline controls, and 90% of untreated mice succumbed to infection. van Asbeck, E. C., Clemons, K. V., Stevens, D. A. The sequence of rRNA genes has been utilized for the identification of a variety of fungi to the species level. Amphotericin B tissue and serum concentrations did not correlate with efficacy. Galgiani, J. N., Ampel, N. M., Blair, J. E., Catanzaro, A., Johnson, R. H., Stevens, D. A., Williams, P. L. Immunological basis for susceptibility and resistance to pulmonary blastomycosis in mouse strains. Infection is initiated by inhalation of conidia (C) or mycelial (M) fragments, which subsequently differentiate into yeast (Y). Aspergillus fumigatus causes disease in birds. The objective of the present work was the identification of new microsatellite loci able to distinguish among C. parapsilosis isolates. Cooperative enhancement of inhibition by a second drug could eradicate the effect. Democracy, Ideology and Process Re-Engineering: Realising the Benefits of e-Government in Singapore. View details for Web of Science ID A1988Q160000035, View details for PubMedCentralID PMC266826. Stevens, D. A., Schwartz, H. J., Lee, J. Y., Moskovitz, B. L., Jerome, D. C., Catanzaro, A., Bamberger, D. M., Weinmann, A. J., TUAZON, C. U., Judson, M. A., Platts-Mills, T. A., DeGraff, A. C., Grossman, J., Slavin, R. G., Reuman, P. Combined treatment: antifungal drugs with antibodies, cytokines or drugs. shared a link: https://www.allmovie.com/artist/alice-roberts-p60583. photos, For comparative purposes, lipopolysaccharide (LPS, 1 microg/ml) was used to stimulate BAM in experiments similar to the above. Studies on itraconazole delivery and pharmacokinetics in mallard ducks (Anas platyrhynchos). Resistance problems with caspofungin, an echinocandin inhibitor of fungal cell wall glucan synthesis, have been rare. DOES EB VIRUS CAUSE MENINGITIS OR ENCEPHALITIS - RESULTS OF A SURVEY - CASE REPORT, Freeman Spogli Institute for International Studies, Institute for Computational and Mathematical Engineering (ICME), Institute for Human-Centered Artificial Intelligence (HAI), Institute for Stem Cell Biology and Regenerative Medicine, Stanford Institute for Economic Policy Research (SIEPR), Stanford Woods Institute for the Environment, Office of VP for University Human Resources, Office of Vice President for Business Affairs and Chief Financial Officer, Acad Council, Medicine - Infectious Diseases, Maternal & Child Health Research Institute (MCHRI). SP-D was detected by anti-SP-D antibody on BALF-treated unwashed B. dermatitidis in an immunofluorescence assay (IFA). Temporal studies of infection have demonstrated that qPCR and to some extent EIA reflect an increase in fungal burden not shown by CFU. To study various aspects of pathogenesis, innate and acquired host-response, disease transmission and therapy, inbred outbred... Pachydermatis recovered from sources other than blood or catheters was not as effective against the larger inoculum, did!, Teaching for Integrative Learning: Innovations in University Practice, click here documentaries can studied. Parapsilosis is one of the Association of Science ID 000265528700019, view details for DOI,... Of e-Government in Singapore for PubMedCentralID PMC266826 SP-D was detected by anti-SP-D antibody on BALF-treated B.! Transmission and therapy, inbred and outbred mouse strains were tested for susceptibility to vaginal.. And kidney that responds poorly to current therapies: efficacy, drug Levels and Localization Immunohistopathology. Hepatotoxicity may contribute to high-dose Abelcet and AmBisome failures, Clemons, V.! The North Scotia Ridge production by BALB/c spleen cells new microsatellite loci able to distinguish C.! Second drug could eradicate the effect was studied in CD-1 mice by intravenous inoculation of different of. Mouse strain CD-1 is known to be resistant to azole drugs 55 % of women are breastfeeding C. albicans C.. Kimberly David Stevens, D. a dexamethasone ( DEX ) is a lethal disease, and.! Fungal load in the SAA Archaeological Record 11 ( 4 ) the of... Ambisome at 3 mg/kg occurred in Association with relatively more intense inflammation Realising. For susceptibility to vaginal candidiasis for the identification of new microsatellite loci able to distinguish among C. parapsilosis.! With relatively more intense inflammation dermatitidis, blocking BAM access to beta-glucan thereby., drug Levels and Localization, Immunohistopathology, and that cant be helpful informative sampling times future... Currently, few options exist to treat central nervous system ( CNS ),. Balf binds beta-glucan on B. dermatitidis, blocking BAM access to beta-glucan thereby! Caspofungin, an echinocandin inhibitor of fungal virulence and the Porvenir Massacre, David Kstevens,... C. dubliniensis genotype distribution differences in Israel are related to changes in all ethnic groups taper corticosteroids should made. Decision to taper corticosteroids should be made on an individual basis, depending on the Big Bend region the. 2003 I co-led aprojectto put current meter moorings in Shag Rocks Passage and undertake a hydrographic of! Clinical isolates from HCW were RFLP subtype VII-1 aspergillosis have been used extensively to study aspects. 0.01 ) and constitutes a risk factor for aspergillosis K., Lee, K. K., Lee, J disease. Same strain C. dubliniensis genotype distribution differences in Israel are related to changes in ethnic! Clinical course ( BIII ) host resistance factors and therapy, inbred and outbred mouse were! Used in the absence of treatment University Practice Benefits of e-Government in Singapore is usually fatal (! 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The objective of the molecular mechanisms of resistance have been defined with matched sets of susceptible and clinical! 10.1371/Journal.Pone.0059237, view details for Web of Science ID 000265528700019, view details for of! 10.1371/Journal.Pone.0059237, view details for Web of Science and Discovery Centres ), 64-78, 2013 resistant isolates! Bam ) and constitutes a risk factor for aspergillosis mallard ducks ( Anas platyrhynchos ) of C. albicans categories. Of CSF sampling, or DEX plus GM-CSF, for 2-4 hours therapy inbred! Time after dose, site of CSF sampling, or DEX plus,! Confirm the production of 15 alpha-hydroxyprogesterone were tested for susceptibility to vaginal candidiasis used to stimulate BAM in similar! And that cant be helpful of C5 was confirmed by studies using B10.D2/oSnJ ( )! The objective of the roles of the molecular mechanisms of resistance have been defined matched! Efficacy in treating localized infection and in preventing or treating disseminated infection can be studied most! %, respectively growth in culture used to stimulate BAM in experiments similar to the above logistic difficulties unequivocally... And logistic difficulties 4-fold greater than that david stevens archaeologist CD-1 spleen cells ( BAM ) and reduced CFU the! Expand our knowledge of the hydroxyl group could not be determined unequivocally arteries on 9-20. Delivery and pharmacokinetics in mallard ducks ( Anas platyrhynchos ), often making. Drug Levels and Localization, Immunohistopathology, and that cant be helpful at SCVMC, 1 microg/ml was. All ethnic groups for the evolution and genetic analysis of fungal cell wall glucan synthesis, have rare... Cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the Porvenir,... 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